Comparative efficacy of platelet-rich plasma and dextrose prolotherapy for stifle joint arthritis in a rabbit model

This study aimed to investigate the efficacy of PRP and dextrose PRL in stifle joint arthritis rabbits.Sixteen healthy adult male rabbits were allocated into groups A (n=8) B (n=8). After induction all experimental animals, animals group treated with intra-articular injection PRP, while PRL. Pain scoring was evaluated by Simple Descriptive scale at 0d, 6d, 13d, 19d, radiographic examined Kellgren Lawrence grading system pre-induction, post-induction, post-treatment. The hematological parameters, including PLT, HB, WBC, PCV, RBC, monocytes, lymphocytes, assessed blood samples 19d. We observed that showed a significantly lower (P<0.05) value than 13d Radiographic during However, pre- post-monoiodoacetate (MIA) induction, there no significant difference (P>0.05) between both groups. PLT concentration increased, monocyte decreased 19d (P<0.05), lymphocyte In conclusion, application is an effective method for treating compared rabbit model.